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BACKGROUND: Freezing all embryos, followed by thawing and transferring them into the uterine cavity at a later stage (freeze-all), instead of fresh-embryo transfer may lead to improved pregnancy rates and fewer complications during in vitro fertilisation and pregnancies resulting from it. OBJECTIVE: We aimed to evaluate if a policy of freeze-all results in a higher healthy baby rate than the current policy of transferring fresh embryos. DESIGN: This was a pragmatic, multicentre, two-arm, parallel-group, non-blinded, randomised controlled trial. SETTING: Eighteen in vitro fertilisation clinics across the UK participated from February 2016 to April 2019. PARTICIPANTS: Couples undergoing their first, second or third cycle of in vitro fertilisation treatment in which the female partner was aged

Original publication

DOI

10.3310/AEFU1104

Type

Journal article

Journal

Health Technol Assess

Publication Date

05/2022

Volume

26

Pages

1 - 142

Keywords

COST-BENEFIT ANALYSIS, EMBRYO TRANSFER, FERTILISATION IN VITRO, FREEZING, FROZEN EMBRYOS, HEALTHY BABY, LIVE BIRTH, OVARIAN HYPERSTIMULATION SYNDROME, PREGNANCY, RANDOMISED CONTROLLED TRIAL, Embryo Transfer, Female, Fertilization in Vitro, Freezing, Humans, Live Birth, Male, Ovarian Hyperstimulation Syndrome, Pregnancy, Pregnancy Rate