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Abstract

Patient-reported outcomes are important measures of clinical care and surgical outcomes. As these measures are increasingly integrated into clinical practice, there is also a need to translate collected data into valuable information to better understand patients’ health trajectories and improve the value of surgical care.

Furthermore, the growing evidence of quality-of-life (QoL) as an important predictor of outcomes suggests that a better understanding of patients’ QoL trajectories can reveal important information on disease progression. Using data from a registry cohort of patients undergoing total knee replacement (TKR) surgery, this study aims to identify unique QoL trajectory groups using latent class growth analysis and to examine patient characteristics of identified trajectories.

There appears to beimportant unobserved heterogeneity in QoL trajectories in patients undergoing TKR. Associating QoL trajectories with patient characteristics can help identify subgroups for whom TKR may be of higher or lower
value, thus facilitate the rational deployment of TKR to those who stand to benefit the most while targeting
others for more appropriate non-surgical intervention.

Forthcoming events

Richard Doll Seminar: Design and analysis of prevalence surveys in low-resource settings

Tuesday, 25 February 2020, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, OX3 7LF

WEH/Ethox Seminar

Wednesday, 26 February 2020, 11am to 12.30pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF

HERC Seminar: Learning healthcare systems for cost-effective precision oncology.

Thursday, 27 February 2020, 12pm to 1pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF

The Global Response to the Novel Coronavirus (SARS-CoV-2) Outbreak

Thursday, 27 February 2020, 2.30pm to 4pm @ Seminar rooms, Big Data Institute

Richard Doll Seminar: The Risk of Everything – using linked electronic health records to develop and validate risk prediction tools for use in clinical care

Tuesday, 03 March 2020, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, OX3 7LF

WEH/Ethox Seminar: Building research capacity through North-South Partnerships: some ethical reflections and a social justice agenda

Wednesday, 04 March 2020, 11am to 12.30pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF