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Abstract

Standard approaches to modelling outcomes commonly include a range of predictors such as age, sex and co-morbidities. However, there is growing evidence that quality-of-life (QoL) is also an important predictor of
mortality.

Whilst the effects of standard risk factors have been adequately captured to describe mortality in most models, the omission of QoL indicates the assumption of full independence between QoL and life expectancy (LE). This omission could give rise to systematic bias when measuring quality-adjusted life years (QALYs).

Using data from a registry cohort of patients undergoing total knee replacement (TKR), potential correlations between baseline utility, change in utility and survival are explored using parametric survival models. Outcomes such as LE, QALYs, and incremental cost-effectiveness ratios (ICERs) were calculated and compared.

Forthcoming events

Richard Doll Seminar: Design and analysis of prevalence surveys in low-resource settings

Tuesday, 25 February 2020, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, OX3 7LF

WEH/Ethox Seminar: Negligence and abortion - doctors' duty of care challenges and potentials in light of Montgomery v Lanarkshire Health Board

Wednesday, 26 February 2020, 11am to 12.30pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF

HERC Seminar: Learning healthcare systems for cost-effective precision oncology.

Thursday, 27 February 2020, 12pm to 1pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF

The Global Response to the Novel Coronavirus (SARS-CoV-2) Outbreak

Thursday, 27 February 2020, 2.30pm to 4pm @ Seminar rooms, Big Data Institute

Richard Doll Seminar: The Risk of Everything – using linked electronic health records to develop and validate risk prediction tools for use in clinical care

Tuesday, 03 March 2020, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, OX3 7LF

WEH/Ethox Seminar: Building research capacity through North-South Partnerships: some ethical reflections and a social justice agenda

Wednesday, 04 March 2020, 11am to 12.30pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF