Harindra Amarasinge
PhD
Postdoctoral Research Scientist in Maternal Sepsis
Harindra is a senior research scientist in the National Perinatal Epidemiology Unit (NPEU). She works on a collaborative project, led by Marian Knight and Julian Knight, on advancing personalised maternal healthcare using genomic-based approaches alongside epidemiological studies.
Prior to her current position, she worked as a postdoctoral research fellow at the Centre for Human Genetics at the Nuffield Department of Medicine, investigating the role of functional genomics plays in extreme immunity. Before that, Harindra worked for the School of Cancer Sciences at the University of Southampton, investigating the clinical utility of genetic and epigenetic biomarkers in treating Chronic Lymphocytic Leukaemia (CLL) patients entered into first-line chemotherapy and chemo-immunotherapy in UK CLL clinical trials.
Harindra received the Open PhD Scholarship for Life Sciences from the University of Leicester and completed her PhD on epigenetics and the evolution of genomic imprinting in a social insect system at the Department of Genetics and Genome Biology at the University of Leicester.
Recent publications
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Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance.
Journal article
Amarasinghe HE. et al, (2023), BMC Genomics, 24
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Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance.
Journal article
Zhang P. et al, (2022), Genome Biol, 23
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Clinico-biological significance of DNA methylation in chronic lymphocytic leukaemia patients: results from three UK clinical trials
Conference paper
Rose-Zerilli M. et al, (2020), LEUKEMIA & LYMPHOMA, 61, 100 - 102
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The clinical importance of DNA methylation signatures in chronic lymphocytic leukemia patients treated with chemo-immunotherapy
Conference paper
Wojdacz TK. et al, (2018), CANCER RESEARCH, 78
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Allele specific expression and methylation in the bumblebee,Bombus terrestris
Journal article
Lonsdale Z. et al, (2017), PeerJ, 5, e3798 - e3798