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Over the past few decades, several anti-obesity medications have demonstrated an association with adverse cardiovascular outcomes, leading to their market withdrawal. This has caused researchers to investigate the cardiovascular safety of such medications in cardiovascular outcome trials. However, the data from these trials are limited, and their outcomes are not promising. Therefore, the aim of this review is to provide an overview of the current and past Food and Drug Administration-approved medications for weight loss, including novel diabetes medications (glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter-2 inhibitors) and non-diabetes medications, and to highlight the current designs of cardiovascular outcome trials and their importance in the evaluation of the overall safety concerns associated with these anti-obesity medications. The limitations of the trials and opportunities for improvement were also evaluated. Finally, we also briefly describe cardiovascular safety and risks in this review.

Original publication

DOI

10.2147/DMSO.S311359

Type

Journal article

Journal

Diabetes Metab Syndr Obes

Publication Date

2021

Volume

14

Pages

3199 - 3208

Keywords

anti-obesity medication, cardiovascular diseases, cardiovascular outcome trials, obesity, obesity therapy, type 2 diabetes mellitus