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OBJECTIVE: To assess obstetric and neonatal outcomes in women with a prior episode of cancer. METHODS: Data were obtained from a linkage between the Scottish Cancer Registry and routinely collected data from Scottish maternity hospitals. Obstetric outcomes in a first pregnancy which ended between 1980 and 2005 were compared in 917 women with, and 5,496 women without, a previous history of cancer. RESULTS: The mean age at delivery was 29 years (standard deviation 5.66) and 26 years (standard deviation 5.62) in the exposed and unexposed groups respectively (P<.001). Multiple logistic regression showed that cancer survivors had higher rates of postpartum hemorrhage (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.09-2.23) and operative or assisted delivery (abdominal or vaginal) (OR 1.33, 95% CI 1.14- 1.54). Preterm delivery (at less than 37 weeks of gesation) was also found to be higher in this group compared with non-cancer women (OR 1.33, 95% CI 1.01-1.76). CONCLUSION: While largely reassuring to women intending to become pregnant after surviving cancer, the results indicate areas of increased risk that require additional surveillance.

Original publication

DOI

10.1097/01.AOG.0000284458.53303.1c

Type

Journal article

Journal

Obstet Gynecol

Publication Date

10/2007

Volume

110

Pages

849 - 854

Keywords

Age of Onset, Cohort Studies, Delivery, Obstetric, Female, Humans, Maternal Age, Neoplasms, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Retrospective Studies, Survivors, United Kingdom