Dr Najaf Amin
Senior Research Associate
Dr. Amin did her masters in statistics from Quaid-e-Azam University Islamabad, Pakistan in 2001. She moved to the Netherlands to pursue higher studies in 2005 on a scholarship awarded by the government of Pakistan. She did her Doctor of Science (DSc) in genetic epidemiology from the Netherlands Institute of Health Sciences in 2007 and received her PhD degree in genetic epidemiology from the Erasmus University Rotterdam, the Netherlands in 2011. From 2011 to 2014 she worked as a post doctoral researcher at the Department of Epidemiology at Erasmus Medical Center, Rotterdam. In 2014 she was promoted to become an assistant professor at the same department. In November 2019 she accepted a senior researcher position at the Nuffield Department of Population Health.
Her main area of research is identifying biomarkers for neuro-psychiatric traits using serum/plasma-based and single cell-based multi-omics research including genomics, epigenomics, transcriptomics, proteomics and metabolomics as well as gut microbiome. Further, she is interested in identifying causal relationships using Mendelian Randomisation and translation of her findings using cell-based research.
She is adept in using contemporary biomarker-mapping techniques related to genomics as well as other omics. She works with genomics data (array and sequence) generated by UK Biobank data and single cell-based transcriptomics, proteomics and metabolomics data in the Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development (ADAPTED) consortium. She has over 300 scientific research papers published in various international journals.
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.
Holstege H. et al, (2022), Nat Genet
The long-term relation between physical activity and executive function in the Rotterdam Study.
Galle SA. et al, (2022), Eur J Epidemiol
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.
Lahti J. et al, (2022), Mol Psychiatry
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Bellenguez C. et al, (2022), Nat Genet
Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping.
Belloy ME. et al, (2022), Alzheimers Res Ther, 14