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We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction (MI). This association was assessed in 7,983 subjects of the Rotterdam Study during 14 years of follow-up. Among 345 subjects who developed a MI, the risk of mortality was 1.49 times higher in the variant carriers of the IGF-I promoter polymorphism than in the nonvariant carriers (95% confidence interval 1.10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI.

Original publication




Journal article


Am J Cardiol

Publication Date





1274 - 1276


Aged, European Continental Ancestry Group, Follow-Up Studies, Heterozygote, Humans, Insulin-Like Growth Factor I, Myocardial Infarction, Netherlands, Polymorphism, Genetic, Promoter Regions, Genetic, Proportional Hazards Models