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We re-annotated the interacting partners of the neuronal scaffold protein DISC1 using a knowledge-based approach that incorporated recent protein interaction data and published literature to. This revealed two highly connected networks. These networks feature cellular function and maintenance, and cell signaling. Of potentially greatest interest was the novel finding of a high degree of connectivity between the DISC1 scaffold protein, linked to psychiatric illness, and huntingtin, the protein which is mutated in Huntington's disease. The potential link between DISC1, huntingtin and their interacting partners may open new areas of research into the effects of pathway dysregulation in severe neurological disorders.

Original publication

DOI

10.1371/journal.pone.0016263

Type

Journal article

Journal

PLoS One

Publication Date

26/01/2011

Volume

6

Keywords

Disease Susceptibility, Humans, Huntingtin Protein, Huntington Disease, Nerve Tissue Proteins, Nervous System Diseases, Nuclear Proteins, Protein Binding