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For many years, there has been interest in a possible link between epilepsy and schizophrenia. A recent study found a strong, bidirectional link between the two conditions: people with one had a higher than average risk of having the other. Using two large data sets of hospital admission data, we investigated whether schizophrenia and epilepsy occur together in individuals more commonly than expected by chance. We undertook a retrospective cohort study using the Oxford Record Linkage Study (ORLS) and English national linked Hospital Episode Statistics to investigate the coexistence of these conditions. There was an elevated risk of epilepsy in people admitted to hospital with schizophrenia (ORLS rate ratio 2.1, 95% confidence interval 1.6-2.6; England 3.0, 2.9-3.1) and an elevated risk of schizophrenia in people admitted to hospital with epilepsy (ORLS 5.1, 4.1-6.2; England 4.5, 4.3-4.6). We found no consistent difference between male and female patients. Schizophrenia and epilepsy occur together in individuals more frequently than expected by chance.

Original publication

DOI

10.1111/j.1528-1167.2011.03390.x

Type

Journal article

Journal

Epilepsia

Publication Date

04/2012

Volume

53

Pages

e71 - e74

Keywords

Adolescent, Adult, Aged, Child, Child, Preschool, Cohort Studies, Epilepsy, Female, Humans, Infant, Infant, Newborn, Male, Medical Record Linkage, Middle Aged, Retrospective Studies, Schizophrenia, Young Adult