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PURPOSE: Vitamin K may inhibit vascular calcification, a common attribute of atherosclerotic vascular diseases (ASVDs). We examined associations between dietary vitamin K1 intakes and both subclinical atherosclerosis and ASVD events, including hospitalisations and mortality, in older women. METHODS: 1,436 community-dwelling women (mean ± SD age 75.1 ± 2.7 years) were included. Vitamin K1 intakes were calculated from a validated food frequency questionnaire at baseline (1998), utilising a region-matched vitamin K food database. Common carotid artery intima-media thickness (CCA-IMT), a measure of subclinical atherosclerosis, was measured in 2001 (n = 1,090). Differences in CCA-IMT by quartiles (Q) of vitamin K1 intake were examined using multivariate analysis of variance. Associations between vitamin K1 intakes and ASVD outcomes (hospitalisations and/or deaths), obtained from linked health records over 14.5 years, were analysed using restricted cubic splines within multivariable-adjusted Cox-proportional hazard models. RESULTS: Women with higher vitamin K1 intakes had a 5.6% lower mean CCA-IMT (Q4 [median 119 µg/day] compared to Q1 [median 49 µg/day], p 

Original publication

DOI

10.1007/s00394-025-03686-x

Type

Journal article

Journal

Eur J Nutr

Publication Date

03/05/2025

Volume

64

Keywords

Coronary heart disease, Nutrition, Phylloquinone, Stroke, Vascular calcification, Humans, Female, Aged, Atherosclerosis, Vitamin K 1, Carotid Intima-Media Thickness, Hospitalization, Diet, Risk Factors, Proportional Hazards Models, Aged, 80 and over