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Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. This randomised trial compared standard whole-breast radiotherapy (WBRT) versus WBRT plus a boost of 16 Gray (Gy) to the tumour bed. Outcomes included overall survival, local control and fibrosis. All patients had stage I and II breast cancer treated with breast-conserving treatment. Here, 20-year follow-up results are presented. This is the key study to demonstrate the value of boost radiotherapy for high local recurrence risk breast cancer.

Original publication





Book title

50 Landmark Papers: Every Breast Surgeon Should Know

Publication Date



225 - 228