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Large placebo-controlled trials have demonstrated kidney and cardiovascular clinical benefits of SGLT-2 inhibitors. Data from the EMPA-KIDNEY and DELIVER trials and associated meta-analyses triggered an update to the UK Kidney Association Clinical Practice Guideline on Sodium-Glucose Co-transporter-2 (SGLT-2) Inhibition in Adults with Kidney Disease. We provide a summary of the full guideline and highlight the rationale for recent updates. The use of SGLT-2 inhibitors in people with specific medical conditions, including type 1 diabetes, kidney transplants, and people admitted to hospital with heart failure is also considered, along with Recommendations for future research and Recommendations for implementation. A full "lay" summary of the guidelines is provided as an appendix to ensure that these guidelines are accessible and understandable to people who are not medical professionals.

Original publication




Journal article


BMC Nephrol

Publication Date





Acute kidney injury, Chronic kidney disease, Gliflozin, Guideline, Adult, Humans, Sodium-Glucose Transporter 2 Inhibitors, Hypoglycemic Agents, Diabetes Mellitus, Type 2, Sodium-Glucose Transporter 2, Blood Glucose, Kidney Diseases, Kidney, Sodium, United Kingdom