The role of NMR-based circulating metabolic biomarkers in development and risk prediction of new onset type 2 diabetes.
Bragg F., Kartsonaki C., Guo Y., Holmes M., Du H., Yu C., Pei P., Yang L., Jin D., Chen Y., Schmidt D., Avery D., Lv J., Chen J., Clarke R., Hill MR., Li L., Millwood IY., Chen Z.
Associations of circulating metabolic biomarkers with type 2 diabetes (T2D) and their added value for risk prediction are uncertain among Chinese adults. A case-cohort study included 882 T2D cases diagnosed during 8-years' follow-up and a subcohort of 789 participants. NMR-metabolomic profiling quantified 225 plasma biomarkers in stored samples taken at recruitment into the study. Cox regression yielded adjusted hazard ratios (HRs) for T2D associated with individual biomarkers, with a set of biomarkers incorporated into an established T2D risk prediction model to assess improvement in discriminatory ability. Mean baseline BMI (SD) was higher in T2D cases than in the subcohort (25.7 [3.6] vs. 23.9 [3.6] kg/m2). Overall, 163 biomarkers were significantly and independently associated with T2D at false discovery rate (FDR) controlled p