Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.
Landi MT., Bishop DT., MacGregor S., Machiela MJ., Stratigos AJ., Ghiorzo P., Brossard M., Calista D., Choi J., Fargnoli MC., Zhang T., Rodolfo M., Trower AJ., Menin C., Martinez J., Hadjisavvas A., Song L., Stefanaki I., Scolyer R., Yang R., Goldstein AM., Potrony M., Kypreou KP., Pastorino L., Queirolo P., Pellegrini C., Cattaneo L., Zawistowski M., Gimenez-Xavier P., Rodriguez A., Elefanti L., Manoukian S., Rivoltini L., Smith BH., Loizidou MA., Del Regno L., Massi D., Mandala M., Khosrotehrani K., Akslen LA., Amos CI., Andresen PA., Avril M-F., Azizi E., Soyer HP., Bataille V., Dalmasso B., Bowdler LM., Burdon KP., Chen WV., Codd V., Craig JE., Dębniak T., Falchi M., Fang S., Friedman E., Simi S., Galan P., Garcia-Casado Z., Gillanders EM., Gordon S., Green A., Gruis NA., Hansson J., Harland M., Harris J., Helsing P., Henders A., Hočevar M., Höiom V., Hunter D., Ingvar C., Kumar R., Lang J., Lathrop GM., Lee JE., Li X., Lubiński J., Mackie RM., Malt M., Malvehy J., McAloney K., Mohamdi H., Molven A., Moses EK., Neale RE., Novaković S., Nyholt DR., Olsson H., Orr N., Fritsche LG., Puig-Butille JA., Qureshi AA., Radford-Smith GL., Randerson-Moor J., Requena C., Rowe C., Samani NJ., Sanna M., Schadendorf D., Schulze H-J., Simms LA., Smithers M., Song F., Swerdlow AJ., van der Stoep N., Kukutsch NA., Visconti A., Wallace L., Ward SV., Wheeler L., Sturm RA., Hutchinson A., Jones K., Malasky M., Vogt A., Zhou W., Pooley KA., Elder DE., Han J., Hicks B., Hayward NK., Kanetsky PA., Brummett C., Montgomery GW., Olsen CM., Hayward C., Dunning AM., Martin NG., Evangelou E., Mann GJ., Long G., Pharoah PDP., Easton DF., Barrett JH., Cust AE., Abecasis G., Duffy DL., Whiteman DC., Gogas H., De Nicolo A., Tucker MA., Newton-Bishop JA., GenoMEL Consortium None., Q-MEGA and QTWIN Investigators None., ATHENS Melanoma Study Group None., 23andMe None., SDH Study Group None., IBD Investigators None., Essen-Heidelberg Investigators None., AMFS Investigators None., MelaNostrum Consortium None., Peris K., Chanock SJ., Demenais F., Brown KM., Puig S., Nagore E., Shi J., Iles MM., Law MH.
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P