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AIM: To measure growth outcomes in preterm infants after introduction of a nutritional care bundle. METHODS: A total of 509 infants of less than 32 weeks' gestation in a level III neonatal intensive care unit in the UK were studied until they were discharged home. Growth and feeding data were extracted from a prospective data registry for 18 months before and after the intervention. The intervention consisted of earlier routine bovine-derived multi-component fortification once the infant has reached 120ml/kg/day of enteral feed from the first day of life and an exclusive human milk diet with routine bovine-derived multi-component fortification of 120 mL/kg/day. RESULTS: After the intervention, growth velocity between birth and 28 days increased from 9.7 ± 4.1 to 12.2 ± 4.6 g/kg/day (mean ± standard deviation), and weight z score change decreased from -1.06 ± 0.56 to -0.76 ± 0.59 (P

Original publication




Journal article


J Paediatr Child Health

Publication Date





444 - 449


extremely preterm, fortifier, human milk, nutrition, very preterm, Animals, Cattle, Food, Fortified, Humans, Infant, Infant, Extremely Premature, Infant, Newborn, Infant, Very Low Birth Weight, Milk, Human, Prospective Studies