Richard Doll Seminar: The genetics of stroke

Abstract

Hugh Markus is Professor of Stroke Medicine and Honorary Consultant Neurologist in the Department of Clinical Neurosciences at the University of Cambridge. He was Professor of Neurology at St George’s, University of London, before moving to his current post in 2013.

He spends approximately half of his time in clinical care of stroke patients. This includes running a National CADASIL/stroke genetics clinic.

His main areas of research interest are the genetics of stroke, where he applies genetic and imaging techniques to investigate the pathogenesis of stroke and develop new treatments, cerebral small vessel disease and clinical trials. He was disease lead for the Wellcome Trust Case Control Consortium 2 (WTCCC2) ischaemic stroke study and established the METASTROKE Genetics consortium.

He has a particular interest in small vessel disease and vascular cognitive impairment and pursues genetic and MRI approaches to investigate disease mechanisms.