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Robert Hills is Professor of Translational Statistics at the Centre for Trials Research, Cardiff University, and Lead for Clinical Cancer Research Methodology.

His interests include novel trial designs to maximise data from patients in increasingly genetically delineated conditions, and meta-analyses of data from different trials, including a recent individual patient data meta-analysis of gemtuzumab ozogamicin (mylotarg) which has been used to support licensing applications in The United States and the EU.

Since 2006 he has worked in Cardiff as statistician for the NCRI Trials in Acute Myeloid Leukaemia, including introducing the multi-arm multi-stage Pick-A-Winner design for older patients not suitable for intensive chemotherapy, which has so far accumulated data on a dozen comparisons. The NCRI AML trials have also accumulated over 10,000 samples, which has allowed investigations of both prognostic and predictive markers. These results have enabled improved risk stratification and the identification of patients who are not well served by current therapy.

In his talk he will explore the story of Mylotarg, from the first randomised controlled trial (AML15) in 2002 through to the recent approval by the FDA last autumn, including the role of the IPD meta-analysis.

Forthcoming events

Amounts, patterns, and micropatterns of physical activity for health: transitioning to wearables data-based guidelines & interventions

Tuesday, 22 October 2024, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, Headington, OX3 7LF

HIV and mpox: where are we in 2024?

Tuesday, 29 October 2024, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, Headington, OX3 7LF

Immune reconstitution inflammatory syndrome in people with HIV: causes and consequences

Monday, 04 November 2024, 1pm to 2pm @ BDI/OxPop Building LG seminar room

Changing the face of trials of medical procedures

Tuesday, 05 November 2024, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, Headington, OX3 7LF