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Abstract

Caroline Relton obtained a PhD in molecular genetics at Newcastle University in 1999 where she then held an academic position for 12 years, before moving to the University of Bristol in 2012. Caroline’s research focuses on understanding the role of both genetic and epigenetic variation in development and disease. The work of her group includes using population-based approaches to study epigenetic information as a biomarker of exposure and a predictor of disease. She has developed and applied causal analysis methods to understand the role of epigenetic processes as disease mechanisms and has led studies investigating the genetic architecture of DNA methylation variation. Her research spans multiple clinical areas from perinatal health to cancer. Caroline is also Director of the Bristol Population Health Science Research Institute.

This lecture will provide some background as to why the fusion of epigenetics and epidemiology may be a fruitful avenue of enquiry in biomedical research, what sorts of questions we can consider addressing, what some of the challenges are and describe some of the solutions that we have developed.

Forthcoming events

Richard Doll Seminar: Design and analysis of prevalence surveys in low-resource settings

Tuesday, 25 February 2020, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, OX3 7LF

WEH/Ethox Seminar: Negligence and abortion - doctors' duty of care challenges and potentials in light of Montgomery v Lanarkshire Health Board

Wednesday, 26 February 2020, 11am to 12.30pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF

HERC Seminar: Learning healthcare systems for cost-effective precision oncology.

Thursday, 27 February 2020, 12pm to 1pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF

The Global Response to the Novel Coronavirus (SARS-CoV-2) Outbreak

Thursday, 27 February 2020, 2.30pm to 4pm @ Seminar rooms, Big Data Institute

Richard Doll Seminar: The Risk of Everything – using linked electronic health records to develop and validate risk prediction tools for use in clinical care

Tuesday, 03 March 2020, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, OX3 7LF

WEH/Ethox Seminar: Building research capacity through North-South Partnerships: some ethical reflections and a social justice agenda

Wednesday, 04 March 2020, 11am to 12.30pm @ Seminar room 0, Big Data Institute, Old Road Campus, OX3 7LF