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This is a five-year study to improve outcomes for patients with bowel cancer across the Yorkshire and Humber. There is evidence of variation in the management of bowel cancer and outcomes for patients across Yorkshire and the Humber.

The study aims to understand the variation and then improve outcomes by addressing these issues. The study will use routine datasets collected during the diagnosis and management of patients with bowel cancer in the NHS. This data is already held by the National Cancer Registration and Analysis Service (NCRAS). NCRAS have linked these datasets together to provide an integrated dataset and we have analysed extracts of this data to provide basic information about bowel cancer care. We now wish to enhance these data further through linkage to new datasets and from data we collect. This will generate high quality intelligence about the management of patients with bowel cancer across Yorkshire and Humber. Additional data will be collected from patients from participating Trusts across the region. We are involving patients in the study to obtain a comprehensive ‘picture’ to understand their quality of life at diagnosis and how this changes over a one year period. This will add to add depth to already available information in order to direct the education programme for the clinical teams.

Patients with bowel cancer being treated in participating hospitals will be asked to consent to participate in the collection of patient reported outcome measures (PROMS) via patient questionnaires. Patients will also be consented for the use of some of their tissue, which is excess to that required for diagnosis and treatment, to be sent to the research team for additional novel biomarker testing. The data from the PROMS and the tissue will be linked to the rest of the integrated dataset in the secure environment within NCRAS.

The study team will use the intelligence to identify clinical areas that could be improved and develop educational programmes to address them specific to the professional group of concern (e.g. pathologists, surgeons), and subsequently assess the impact of these educational interventions on the outcomes of bowel cancer patients in Yorkshire and Humber. The updated data will provide information about the services at the start of the programme and then enable the study team to analyse changes in outcomes across the years.

More information about the Yorkshire Cancer Research Bowel Cancer Improvement Programme can be found here.

Project Outputs:

Taylor JC, Rossington HL, Finan PJ, West NP, Glover A, Mara J, Hindley A, Wright P, Tolan DJ, Swinson D, Seymour MT, Sebag-Montefiore D, Morris EJA, Quirke P. A regional multidisciplinary team intervention programme to improve colorectal cancer outcomes: the Yorkshire Cancer Research Bowel Cancer Improvement Programme. BMJ Open 2019 http://dx.doi.org/10.1136/bmjopen-2019-030618

 

Taylor JC, Swinson D, Seligmann JF, Birch RJ, Dewdney A, Brown V, Dent J, Rossington H, Quirke P, Morris EJA. Addressing the variation in adjuvant chemotherapy treatment for colorectal cancer: can a regional intervention promote national change? Int J Cancer 2020 In press

 

Brown PJ, Rossington H, Taylor J, Lambregts DMJ, Morris EJA, West NP, Quirke P, Tolan D on behalf of the YCR BCIP Study group. Radiologist and multidisciplinary team clinician opinions on the quality of MRI rectal cancer staging reports: how are we doing? Clin Radiol 20189 74(8):637-642

 

Brown PJ, Rossington H, Taylor J, Lambregts DMJ, Morris E, West NP, Quirke P, Tolan D on behalf of the YCR BCIP study group. Standardised reports with a template format are superior to free text reports: the case for rectal cancer reporting in clinical practice. Eur Radiol 2019 29(9):5121-5128

 

Additional loss of MSH2 and MSH6 expression in sporadic deficient mismatch repair colorectal cancer due to MLH1 promoter hypermethylation. Alice Westwood, Amy Glover, Gordon Hutchins, Caroline Young, Scarlet Brockmoeller, Rachel Robinson, Lisa Worrilow, Dave Wallace, Kate Rankeillor, Julian Adlard, Philip Quirke, Nicholas West, Journal of Clinical Pathology 2019

 

Current concepts in imaging for local staging of advanced rectal cancer. P.J.Brown, R. Hyland, A.J.Quyn, N.P.West, D. Sebag-Montefiore, D. Jayne, P.Sagar, D.J.Tolan.

 

What factors determine specimen quality in colon cancer surgery? – A cohort study. Kheng-Seong NG, Nicholas. P. West, Nigel Scott, Melanie Holzgang, Phil Quirke and David,G. Jayne