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Background

Arthritis is one of the leading causes of disability worldwide and is associated with increased risk of various other conditions. The most common types of arthritis (osteoarthritis, rheumatoid arthritis and gout) have different risk factors, aetiology, clinical presentation and disease course. The aims of this project are to investigate the incidence, risk factors and co-morbidities of these diseases using data on 1 million people, 0.5M from the China Kadoorie Biobank (CKB) and 0.5M from the UK Biobank (UKB). The project will:

  • Compare the incidence of major types of arthritis in UK and China;
  • Identify risk factors (using questionnaire data, genetic and other blood-based measurements)  for the major types of arthritis;
  • Quantify the risks of other conditions in individuals with the different types of arthritis.

The focus of the project can be refined to match the interests of the candidate. For further information see http://www.ckbiobank.org/ and http://www.ukbiobank.ac.uk/.

Research Experience, Research Methods and Training

The student will work within a multidisciplinary team including statisticians, epidemiologists and biomedical scientists. He/she will gain experience in the statistical analysis and handling of large-scale data, interpretation and dissemination of results.

Field Work, Secondments, Industry Placements and Training

There will be training opportunities in statistical programming and other courses provided by the Department and the University of Oxford.

Prospective Candidate

Candidates should have a degree in statistics, mathematics, or similar subject (MSc or equivalent desirable), with an interest in medical research, or medicine or biology with a strong interest and some experience in statistics.

Supervisors

Projects

Related research themes