Determinants of mild cognitive impairment in older people with and without prior cardiovascular disease in China: the China Kadoorie Biobank study
Project Reference: NDPH/MT16/034
Studies in Western populations have highlighted the importance of cardiovascular disease (CVD) risk factors for mild cognitive impairment (MCI) and dementia. Stroke is the most common cause of death and disability in China and studies of mild cognitive impairment and dementia in China should be particularly informative. The China Kadoorie Biobank (CKB) study is a prospective study of 0.5M people aged 40-69 years when first examined in 2004-2008. To date, ~40K suffered a stroke and 20K heart disease. Periodic resurveys of 25,000 were conducted in 2010 and 2014 and a further re-survey is planned for 2017.
Research Experience, Research Methods and Training
This thesis will examine (i) review instruments to screen for MCI in setting of illiteracy; (ii) pilot the introduction of a screening questionnaire for MCI to be administered to the 3rd re-survey in CKB; (iii) devise and supervise the delivery of an informant questionnaire administered by telephone to survivors of stroke to assess cognitive function and ability to conduct activities of daily in survivors of stroke; and (iii) to examine the associations of MCI with cardiovascular risk factors, carotid plaques and CIMT using available data.
Field Work, Secondments, Industry Placements and Training
The candidate will be involved in field work to design and supervise the screening tests for MCI to use in the 3rd re-survey and telephone survivors with prior stroke. The project will involve conventional statistical analyses in people with or without prior CVD.
A degree in medicine or biomedical science candidate, preferably with a prior MSc in epidemiology, statistics or global health science and interest in neuropsychological testing.