We have conducted research on chronic non‑communicable diseases since the Health Economics Research Centre was established in 1996, with long‑standing programmes in diabetes and cardiovascular disease.

Our work in diabetes includes major randomised trials in type 2 diabetes (UKPDS, EXSCEL, TECOS and ASCEND) and prediabetes (ACE, NAVIGATOR).

We developed the UKPDS Outcomes Model, now used by more than 200 groups worldwide to inform healthcare decision‑making, and are extending this work through complementary economic models for prediabetes and type 1 diabetes. We recently advised the National Institute for Health and Care Excellence (NICE) on the use of the model in their latest guideline for type 2 diabetes.

Current research includes the REDDIE project on synthetic data, software development for a type 1 diabetes model, and methodological work examining diabetes inequalities, secular trends, trial generalisability and data‑driven diabetes subgroups.

We have undertaken economic evaluations alongside major Clinical Trial Service Unit and Epidemiological Studies Unit trials and the Cholesterol Treatment Trialists’ Collaboration, contributing evidence to support national and international policy decisions.

In kidney disease, we contribute to the EMPA‑KIDNEY trial and associated modelling work to assess long‑term outcomes, costs and implications for resource allocation.