Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
Benjamin EJ., Rice KM., Arking DE., Pfeufer A., van Noord C., Smith AV., Schnabel RB., Bis JC., Boerwinkle E., Sinner MF., Dehghan A., Lubitz SA., D'Agostino RB., Lumley T., Ehret GB., Heeringa J., Aspelund T., Newton-Cheh C., Larson MG., Marciante KD., Soliman EZ., Rivadeneira F., Wang TJ., Eiríksdottir G., Levy D., Psaty BM., Li M., Chamberlain AM., Hofman A., Vasan RS., Harris TB., Rotter JI., Kao WHL., Agarwal SK., Stricker BHC., Wang K., Launer LJ., Smith NL., Chakravarti A., Uitterlinden AG., Wolf PA., Sotoodehnia N., Köttgen A., van Duijn CM., Meitinger T., Mueller M., Perz S., Steinbeck G., Wichmann H-E., Lunetta KL., Heckbert SR., Gudnason V., Alonso A., Kääb S., Ellinor PT., Witteman JCM.
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).