The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.
Watts EL., Perez-Cornago A., Appleby PN., Albanes D., Ardanaz E., Black A., Bueno-de-Mesquita HB., Chan JM., Chen C., Chubb SAP., Cook MB., Deschasaux M., Donovan JL., English DR., Flicker L., Freedman ND., Galan P., Giles GG., Giovannucci EL., Gunter MJ., Habel LA., Häggström C., Haiman C., Hamdy FC., Hercberg S., Holly JM., Huang J., Huang W-Y., Johansson M., Kaaks R., Kubo T., Lane JA., Layne TM., Le Marchand L., Martin RM., Metter EJ., Mikami K., Milne RL., Morris HA., Mucci LA., Neal DE., Neuhouser ML., Oliver SE., Overvad K., Ozasa K., Pala V., Pernar CH., Pollak M., Rowlands M-A., Schaefer CA., Schenk JM., Stattin P., Tamakoshi A., Thysell E., Touvier M., Trichopoulou A., Tsilidis KK., Van Den Eeden SK., Weinstein SJ., Wilkens L., Yeap BB., Key TJ., Allen NE., Travis RC.
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural, and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I, IGF-II) and IGFBPs (IGFBP-1, IGFBP-2, IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II, and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than non-smokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural, and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk. This article is protected by copyright. All rights reserved.