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The alpha 1-antichymotrypsin (ACT) A allele was recently associated with Alzheimer's disease (AD), and the ACT AA genotype was reported to be more frequent in AD subjects with the apolipoprotein E (APOE) epsilon4 allele. We examined ACT and APOE genotypes in a sample of 160 subjects with probable AD and in 102 elderly control subjects. ACT A allele frequencies were similar in AD subjects (0.503) and elderly controls (0.519). In addition, we found no evidence that in AD the AA genotype is more frequent in subjects with the APOE epsilon4 allele than in those without it. Our results do not support an association between the ACT A allele and AD.

Type

Journal article

Journal

Neurology

Publication Date

05/1997

Volume

48

Pages

1313 - 1316

Keywords

Adult, Aged, Alleles, Alzheimer Disease, Apolipoprotein E4, Apolipoproteins E, Female, Gene Frequency, Genotype, Heterozygote, Humans, Male, Middle Aged, Reference Values, alpha 1-Antichymotrypsin