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The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease in 99 Dutch and 78 Spanish patients. In patients with early-onset AD, we found no consistent relationship with a single allele of the -491 polymorphism. Linkage disequilibrium between the polymorphism and the APOE gene was found which most likely might explain the inconsistent findings.


Journal article


Neurosci Lett

Publication Date





65 - 68


Age of Onset, Alleles, Alzheimer Disease, Apolipoproteins E, Chromosomes, Human, Pair 19, Gene Frequency, Genetic Linkage, Genetic Testing, Genotype, Humans, Linkage Disequilibrium, Middle Aged, Point Mutation, Polymorphism, Genetic, Regulatory Sequences, Nucleic Acid