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We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.

Original publication

DOI

10.1016/j.amjcard.2004.04.044

Type

Journal article

Journal

Am J Cardiol

Publication Date

01/08/2004

Volume

94

Pages

384 - 386

Keywords

Age Distribution, Alleles, Cohort Studies, Confidence Intervals, Female, Genetic Predisposition to Disease, Heart Failure, Humans, Incidence, Insulin-Like Growth Factor I, Male, Polymorphism, Genetic, Prognosis, Promoter Regions, Genetic, Proportional Hazards Models, Prospective Studies, Risk Assessment, Sex Distribution, Survival Analysis