Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Humans sleep approximately a third of their lifetime. The observation that individuals with either long or short sleep duration show associations with metabolic syndrome and psychiatric disorders suggests that the length of sleep is adaptive. Although sleep duration can be influenced by photoperiod (season) and phase of entrainment (chronotype), human familial sleep disorders indicate that there is a strong genetic modulation of sleep. Therefore, we conducted high-density genome-wide association studies for sleep duration in seven European populations (N=4251). We identified an intronic variant (rs11046205; P=3.99 × 10(-8)) in the ABCC9 gene that explains ≈5% of the variation in sleep duration. An influence of season and chronotype on sleep duration was solely observed in the replication sample (N=5949). Meta-analysis of the associations found in a subgroup of the replication sample, chosen for season of entry and chronotype, together with the discovery results showed genome-wide significance. RNA interference knockdown experiments of the conserved ABCC9 homologue in Drosophila neurons renders flies sleepless during the first 3 h of the night. ABCC9 encodes an ATP-sensitive potassium channel subunit (SUR2), serving as a sensor of intracellular energy metabolism.

Original publication

DOI

10.1038/mp.2011.142

Type

Journal article

Journal

Mol Psychiatry

Publication Date

01/2013

Volume

18

Pages

122 - 132

Keywords

ATP-Binding Cassette Transporters, Adolescent, Adult, Aged, Aged, 80 and over, Animals, Animals, Genetically Modified, Cohort Studies, Drosophila, Drosophila Proteins, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Kv1.3 Potassium Channel, Male, Middle Aged, Myocardium, Phenotype, Photoperiod, Plakophilins, Polymorphism, Single Nucleotide, Potassium Channels, Inwardly Rectifying, RNA Interference, Receptors, Drug, Repressor Proteins, Sleep Wake Disorders, Sulfonylurea Receptors, Young Adult