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BACKGROUND: Significant differences between individual responses to emotional stimuli can be important for the study of emotion. We investigated whether incorporating individual ratings of emotional arousal in the analysis of functional magnetic resonance imaging (fMRI) data improves the detection of activation in the medial prefrontal cortex (MPFC) and sublenticular extended amygdala (SLEA), areas implicated in the processing of emotional salience. METHODS: Healthy subjects viewed counterbalanced blocks of aversive, nonaversive, and blank images. Outside the scanner, they rated the intensity of emotional arousal (salience) of each presented picture. RESULTS: Incorporating the subject's response to each stimulus by using individualized regressors produced more robust activations within MPFC and SLEA compared with a simple boxcar regressor, identical for all subjects. CONCLUSIONS: Our findings demonstrate that individual behavioral data are useful in improving detection of activation in block-design functional imaging studies.

Type

Journal article

Journal

Biol Psychiatry

Publication Date

01/02/2003

Volume

53

Pages

211 - 215

Keywords

Adult, Amygdala, Arousal, Brain Mapping, Corpus Striatum, Emotions, Female, Humans, Image Processing, Computer-Assisted, Individuality, Magnetic Resonance Imaging, Male, Nerve Net, Prefrontal Cortex