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Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.

Original publication

DOI

10.1186/s13073-017-0475-4

Type

Journal article

Journal

Genome Med

Publication Date

25/09/2017

Volume

9