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To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Original publication

DOI

10.1038/ncomms10495

Type

Journal article

Journal

Nat Commun

Publication Date

01/02/2016

Volume

7

Keywords

Adiposity, Animals, Drosophila melanogaster, Gene Expression Regulation, Gene Knockdown Techniques, Genetic Predisposition to Disease, Genome-Wide Association Study, Heart Diseases, Humans, Quantitative Trait Loci