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BACKGROUND: Young women with neurofibromatosis type 1 (NF1) are reported to have a higher risk of breast cancer than others, and this might have implications for screening programmes. Our aim was to calculate this risk. METHODS: An all-England linked data set of hospital admissions and deaths was analysed to determine age-specific rates of breast cancer in women with NF1 and controls. RESULTS: The age-specific excess risk of breast cancer, comparing the NF1 cohort with the control cohort, was elevated 6.5-fold (95% confidence interval 2.6-13.5) in women aged 30-39 years. There was a 4.4 (2.5-7.0) times higher risk among women aged 40-49. CONCLUSIONS: Women with NF1 develop breast cancer at younger ages than the general population.

Original publication

DOI

10.1038/bjc.2015.78

Type

Journal article

Journal

Br J Cancer

Publication Date

28/04/2015

Volume

112

Pages

1546 - 1548

Keywords

Adult, Age Factors, Aged, Aged, 80 and over, Breast Neoplasms, Case-Control Studies, England, Female, Follow-Up Studies, Humans, Middle Aged, Neurofibromatosis 1, Prognosis, Risk Factors