Allan CL., Topiwala A., Ebmeier KP.
Hypomania is characterized by elevated mood in addition to behavior change including increased energy, increased confidence, increased activity, impulsivity, irritability, disinhibition and a reduced need for sleep. Some of these symptoms present practical difficulties for neuroimaging research, for example, consent to receiving radioactive substances during research requires a sound judgment of risks that may be absent in patients with manic symptoms. Nevertheless, there is cross-modal consensus that active manic symptoms are associated with fronto-limbic imbalance, affecting functional and structural connectivity. Specific symptom of mania can be mapped onto neural networks.