Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Acute myeloid leukaemia (AML) with 3q26 cytogenetic abnormalities is associated with overexpression of EVI1, dysmegakaryopoiesis and poor prognosis. Screening for EVI1 transcripts was performed in 336 cases of AML, including 139 patients with acute promyelocytic leukaemia (APL). Expression was detected in 7 out of 10 cases with and 23 out of 326 without 3q26 abnormalities including one APL case. Among cases lacking 3q abnormalities, detection of EVI1 transcripts was neither associated with characteristic dysmegakaryopoietic features, nor predictive of a poor outcome, indicating that screening will probably not assist in treatment stratification. This study nevertheless demonstrates that deregulation of EVI1, although rare in APL, is a relatively frequent event in AML.

Type

Journal

Br J Haematol

Publication Date

01/2001

Volume

112

Pages

208 - 211

Keywords

Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, DNA-Binding Proteins, Female, Humans, Karyotyping, Leukemia, Myeloid, Leukemia, Promyelocytic, Acute, Male, Middle Aged, Proto-Oncogenes, Risk Factors, Transcription Factors