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This report presents a historical and descriptive account of randomized trials in childhood leukaemia since the earliest such studies in the 1960s. It focuses on trials that began before 1988, making use of the register of trials developed for a systematic review of treatments for acute lymphoblastic leukaemia in children. The number of randomized trials starting each year increased from one or two in the 1960s to an annual average of five or six in the 1980s. However trials remained relatively small, with more than half of all randomizations accruing less than 200 patients and only five having more than 1000. Most trials were published more than once.

Type

Journal article

Journal

Br J Haematol

Publication Date

09/2002

Volume

118

Pages

986 - 990

Keywords

Adolescent, Adult, Child, Child, Preschool, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Randomized Controlled Trials as Topic