A wide landscape of morbidity and mortality risk associated with marital status in 0.5 million Chinese men and women: a prospective cohort study.
Xiao M., Li A., Wang Y., Yu C., Pang Y., Pei P., Yang L., Chen Y., Du H., Schmidt D., Avery D., Sun Q., Chen J., Chen Z., Li L., Lv J., Sun D., China Kadoorie Biobank Collaborative Group None.
BACKGROUND: A comprehensive depiction of long-term health impacts of marital status is lacking. METHODS: Sex-stratified phenome-wide association analyses (PheWAS) of marital status (living with vs. without a spouse) were performed using baseline (2004-2008) and follow-up information (ICD10-coded events till Dec 31, 2017) from the China Kadoorie Biobank (CKB). We estimated adjusted hazard ratios (aHRs) to evaluate the associations of marital status with morbidity risks of phenome-wide significant diseases or sex-specific top-10 death causes in China documented in 2017. Additionally, the association between marital status and mortality risks among participants with major chronic diseases at baseline was assessed. FINDINGS: During up to 11.1 years of the median follow-up period, 1,946,380 incident health events were recorded among 210,202 men and 302,521 women aged 30-79. Marital status was found to have phenome-wide significant associations with thirteen diseases among men (p