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OBJECTIVE: The goal of this systematic-review and meta-analysis was to assess whether high maternal stress during pregnancy is associated with the development of pediatric pathology. DESIGN: Epidemiological peer-reviewed studies published in English or Spanish assessing associations between maternal stress during pregnancy and psychiatric and medical diseases were selected. PARTICIPANTS: We retrieved 73,024 citations; 42 studies meeting inclusion criteria were assessed. Overall sample included 65,814,076 women. FINDINGS: Overall odds ratio for the development of a medical disease was OR=1.24 (CI95=1.11, 1.39), Z=3.85, p

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Diseases, Embryonic and fetal development, Physiological stress, Pregnancy, Psychological stress, Autism Spectrum Disorder, Female, Humans, Obesity, Odds Ratio, Pregnancy, Pregnancy Trimester, First, Prenatal Exposure Delayed Effects