BackgroundThe diagnosis, management and prognosis of microinvasive breast carcinoma remain controversial.MethodsWe analysed the outcomes of patients with DCIS with and without microinvasion diagnosed between 2003 and 2012 within the Sloane project.ResultsMicroinvasion was recorded in 521 of 11,285 patients (4.6%), with considerable variation in reported incidence among screening units (0-25%). Microinvasion was associated with high-grade DCIS, larger DCIS size, comedo necrosis and solid, cribriform architecture (all P ConclusionsThe higher breast cancer mortality with microinvasion indicates a more aggressive disease.
British journal of cancer
Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, UK. firstname.lastname@example.org.