Clonal dissemination of mcr-1.1-positive Escherichia coli ST10 among healthy children in geographically-distant cities.
Yassine I., Fayad S., Tajani AG., Hassan JW., Eltai NO., Ericson JE., Schiff SJ., Naas T., Bisha B., Osman M., Kassem II.
The mobile colistin resistance gene, mcr-1, encodes resistance to colistin, a critically important antibiotic. Resistance to colistin can jeopardize antimicrobial chemotherapy. Here, we report the detection and genomic characterization of mcr-1-carrying Escherichia coli isolated from otherwise healthy children in community daycares. The mcr-1 was located on transferable plasmids. Additionally, the mcr-1 occurred in E. coli that mainly belonged to a clonal ST10 lineage, indicating that these mcr-1-carrying strains were circulating across daycares in geographically-distant cities.