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Naturally acquired immunity to Streptococcus pneumoniae is partially dependent on antibody to protein antigens, with IgG present in pooled adult sera to around 150 proteins. Using mouse models and human samples my group has investigated the dynamics of the development of IgG responses to S. pneumoniae protein antigens and some of the host and bacterial factors that influence antigen selection. These data will help inform on why immunity to S. pneumoniae wanes with age, and potential approaches to prevent this. 

I am an academic respiratory consultant with a subspecialty interest in lung infection. I lead a team at University College London investigating the pathogenesis and mechanisms of immunity for pneumonia. Since 2003 my laboratory has investigated the bacterial and host factors involved in the pathogenesis of infection projects by the commonest cause of pneumonia Streptococcus pneumoniae, as well as novel vaccine approaches to prevent infections that have led to two early phase clinical trials. More recently in a collaboration with Thai investigators we have started a project developing an antibody therapy for the AMR pneumonia pathogen Acinetobacter baumannii. In addition, I conduct translational research into patients with bronchiectasis, pneumonia, and COVID. 

Forthcoming events

The impact of host and virus genetic variation on HCV infection outcome

Monday, 20 May 2024, 1pm to 2pm @ BDI/OxPop Building LG seminar rooms

The Neonatology Canon Project: Examining the Research Endeavor Through Comprehensive Aggregation of Randomized Aggregation of Randomized Trials

Tuesday, 21 May 2024, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, Headington, OX3 7LF

Opium as a carcinogen: new insights from the Golestan Cohort Study

Tuesday, 28 May 2024, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, Headington, OX3 7LF

Exploiting electronic health records to improve infection management

Monday, 03 June 2024, 1pm to 2pm @ BDI/OxPop Building LG seminar rooms

Title TBC

Tuesday, 04 June 2024, 1pm to 2pm @ Richard Doll Lecture Theatre, Richard Doll Building, Old Road Campus, Headington, OX3 7LF