Clonal dissemination of mcr-1.1-positive Escherichia coli ST10 among healthy children in geographically-distant cities.

Yassine I., Fayad S., Tajani AG., Hassan JW., Eltai NO., Ericson JE., Schiff SJ., Naas T., Bisha B., Osman M., Kassem II.

The mobile colistin resistance gene, mcr-1, encodes resistance to colistin, a critically important antibiotic. Resistance to colistin can jeopardize antimicrobial chemotherapy. Here, we report the detection and genomic characterization of mcr-1-carrying Escherichia coli isolated from otherwise healthy children in community daycares. The mcr-1 was located on transferable plasmids. Additionally, the mcr-1 occurred in E. coli that mainly belonged to a clonal ST10 lineage, indicating that these mcr-1-carrying strains were circulating across daycares in geographically-distant cities.

DOI

10.1016/j.ajic.2026.03.002

Type

Journal article

Publication Date

2026-03-11T00:00:00+00:00

Keywords

Escherichia coli, antibiotic resistance, children, colistin, community, mcr-1

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