Dr Najaf Amin
Senior Research Associate
Dr. Amin did her masters in statistics from Quaid-e-Azam University Islamabad, Pakistan in 2001. She moved to the Netherlands to pursue higher studies in 2005 on a scholarship awarded by the government of Pakistan. She did her Doctor of Science (DSc) in genetic epidemiology from the Netherlands Institute of Health Sciences in 2007 and received her PhD degree in genetic epidemiology from the Erasmus University Rotterdam, the Netherlands in 2011. From 2011 to 2014 she worked as a post doctoral researcher at the Department of Epidemiology at Erasmus Medical Center, Rotterdam. In 2014 she was promoted to become an assistant professor at the same department. In November 2019 she accepted a senior researcher position at the Nuffield Department of Population Health.
Her main area of research is identifying biomarkers for neuro-psychiatric traits using serum/plasma-based and single cell-based multi-omics research including genomics, epigenomics, transcriptomics, proteomics and metabolomics as well as gut microbiome. Further, she is interested in identifying causal relationships using Mendelian Randomisation and translation of her findings using cell-based research.
She is adept in using contemporary biomarker-mapping techniques related to genomics as well as other omics. She works with genomics data (array and sequence) generated by UK Biobank data and single cell-based transcriptomics, proteomics and metabolomics data in the Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development (ADAPTED) consortium. She has over 300 scientific research papers published in various international journals.
Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants.
Young KL. et al, (2023), HGG Adv, 4
Gut microbiome-wide association study of depressive symptoms.
Radjabzadeh D. et al, (2022), Nat Commun, 13
Interplay of the human exposome, metabolome and gut microbiome in dementia and major depression
van Duijn CM. et al, (2022), Alzheimer's and Dementia, 18
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.
Holstege H. et al, (2022), Nat Genet
Sociodemographic, lifestyle and clinical characteristics of energy-related depression symptoms: A pooled analysis of 13,965 depressed cases in 8 Dutch cohorts.
Vreijling SR. et al, (2022), J Affect Disord