Associate Professor Michael Holmes
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses.
Wang W. et al, (2021), Nutr Metab Cardiovasc Dis
Causal effects of gallstone disease on risk of gastrointestinal cancer in Chinese.
Pang Y. et al, (2021), Br J Cancer
Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development.
Holmes MV. et al, (2021), Nat Rev Cardiol
Colocalization analysis of polycystic ovary syndrome to identify potential disease-mediating genes and proteins.
Censin JC. et al, (2021), Eur J Hum Genet
Big data bring big controversies: HDL cholesterol and mortality.
Ala-Korpela M. et al, (2021), Int J Epidemiol