Dr Michael Holmes
|Tel||+44 (0)1865 743644|
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
Senior Clinical Research Fellow in Cardiovascular Medicine
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation.
Wang Q. et al, (2017), Diabetes Care, 40, 1779 - 1786
Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis.
Harrison SC. et al, (2017), JAMA Cardiol
Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults.
Millwood IY. et al, (2017), JAMA Cardiol
Dyslipidaemia: Revealing the effect of CETP inhibition in cardiovascular disease.
Holmes MV. and Smith GD., (2017), Nat Rev Cardiol, 14, 635 - 636
Correcting the Standard Errors of 2-Stage Residual Inclusion Estimators for Mendelian Randomization Studies.
Palmer TM. et al, (2017), Am J Epidemiol, 186, 1104 - 1114