Associate Professor Michael Holmes
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology.
Bovijn J. et al, (2019), Am J Hum Genet, 104, 157 - 163
A review of lifestyle, metabolic risk factors and blood-based biomarkers for early diagnosis of pancreatic ductal adenocarcinoma.
Pang Y. et al, (2018), J Gastroenterol Hepatol
GWAS identifies 14 loci for device-measured physical activity and sleep duration.
Doherty A. et al, (2018), Nat Commun, 9
Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment
Sliz E. et al, (2018), Circulation, 138, 2499 - 2512
Leukocyte telomere length and risk of coronary heart disease and stroke mortality: prospective evidence from a Russian cohort.
Stefler D. et al, (2018), Sci Rep, 8