Associate Professor David Eyre
- Robertson Fellow
- Infectious Diseases Clinician
My research interests include the use of whole-genome sequencing as a tool for understanding the epidemiology and transmission of bacterial and fungal pathogens. My previous work has described the transmission of the major healthcare-associated pathogen Clostridium difficile and has also included large-scale sequencing projects tracking the spread of gonorrhoea and the emerging multi-drug resistant fungus Candida auris. I am currently working on developing mathematical models for pathogen transmission that allow risk factors for transmission to be identified, as a means to suggest potential interventions to prevent infections spreading.
I am also interested in using sequencing technologies as a novel tool for culture-independent microbiology diagnostics. These technologies offer the prospect of same-day diagnosis of infection, rather than having to wait several days for bacteria to grow in the lab. I have developed methods using sequencing data to detect the presence of infection, e.g. from orthopedic devices removed from patients, as well as predict antibiotic resistance, e.g. in Enterobacteriaceae and Neisseria gonorrhoeae.
Additionally I work on using routinely collected healthcare data to investigate the epidemiology of infectious diseases and to investigate individual patient responses to infection and treatment.
I work closely with the Modernising Medical Microbiology consortium on several of these projects.
Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom
Wei J. et al, (2021), Nature Microbiology
Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time
Walker AS. et al, (2021), eLife, 10
Impaired antibody response to COVID-19 vaccination in patients with chronic myeloid neoplasms.
Chowdhury O. et al, (2021), Br J Haematol
Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy.
Knight DR. et al, (2021), Elife, 10
Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom.
Pritchard E. et al, (2021), Nat Med