Assessing the environmental and genetic causes of lung cancer in never-smokers
Project Reference: NDPH/MT16/038
Although the majority of lung cancer is attributed to tobacco smoke, approximately 25% of lung cancers worldwide occur in lifelong never smokers, lung cancer in never smokers (LCINS) is the 7th cause of cancer-related mortality in the world. Earlier epidemiological studies have identified several environmental risk factors for LCINS, such as passive smoking, occupational exposure and indoor air pollution. LCINS is more frequent in women, which suggests a hormonal element that may interact with other risk factors. Several genetic studies have identified genetic variants associated with risk of LCINS, e.g. CYP1A1 Ile462Val and XRCC1 Arg399Gln. Most previous studies were conducted in Western populations, and there is no dominant risk factor whose significance has been confirmed across racial and ethnic groups. This is particularly important in China where the lifestyles are very different from Western countries, particular for women, e.g. regular smoking is rare, reproductive profiles differ and few use HRT.
China Kadoorie Biobank (CKB) is a large blood-based prospective study, covering 0.5 million adults aged 30-79 years recruited from 10 diverse regions in China during 2004-8. There were 316,209 never-smokers, including 30,118 men (14.5% of all men recruited) and 286,091 women (95% of all women). A subset of ~91,000 randomly selected participants have been genotyped for several genetic variants (SNPs) previously associated with smoking behavior and lung cancer, and genome-wide SNP genotyping is underway for ~100,000 participants. By Dec. 2013, there were 1405 LCINS cases (199 men and 1206 women). It is expected that a further 500 new cases will accrue during 2014-15.
Research Experience, Research Methods and Training
The DPhil student will study the association between the risk of lung cancer and environmental factors and gene-environmental interactions, among Chinese never smokers through:
- Conducting thorough literature reviews;
- Providing reliable estimates of the strength of the relationships between environmental risk factors and LCINS;
- Using genetic data to explore gene:environment interactions, causal associations, and identify novel genetic risk factors for LCINS.
The specific line of investigation will be subject to further discussion and personal interest.
Field Work, Secondments, Industry Placements and Training
By the end of the DPhil, it is expected that the student will be competent to plan, undertake and interpret statistical analysis of large-scale epidemiological data, to publish 3-5 peer-reviewed papers and to report research findings at relevant meetings.
An additional supervisor (to be confirmed) will be appointed prior to the commencement of study for any applicant accepted to this project.
Candidate should have at least 2.1 degree in medical sciences and an MSc in public health fields would be an advantage. The project will requires some previous statistical and programming training/experience.