Effects of Integrase Inhibitor-Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV.

Toribio M., Burdo TH., Fulda ES., Cetlin M., Chu SM., Feldpausch MN., Robbins GK., Neilan TG., Melbourne K., Grinspoon SK., Zanni MV.

The NOD-like receptor protein family pyrin domain containing 3 (NLRP3) inflammasome, activated in the setting of HIV, contributes to pro-atherogenic inflammation. Among antriretroviral therapy-naïve people with HIV (vs controls), levels of caspase-1-a key component of the NLRP3 inflammasome-were significantly increased. Six months of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate significantly decreased caspase-1 levels in association with CD4+/CD8+ ratio recovery. Trial registration. ClinicalTrials.gov NCT01766726.

DOI

10.1093/ofid/ofaa459

Type

Journal article

Publication Date

2020-10-01T00:00:00+00:00

Volume

7

Keywords

HIV, NLRP3 inflammasome, atherosclerosis, cardiovascular disease, caspase-1, pyroptosis

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