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BACKGROUND: Invasive infections due to Haemophilus influenzae are infrequent following the implementation of vaccination against H. influenzae of serotype b. However, their changing epidemiology may not be clear due to a lack of appropriate genotyping methods combined with antibiotic susceptibility analyses which do not discriminate invasive and non-invasive isolates. We aimed to describe recent epidemiological trends of invasive H. influenzae infections in France and explore the microbiological characteristics of invasive versus non-invasive isolates. METHODS: All culture- and PCR-confirmed cases due to H. influenzae isolated from a sterile site, that were received at the French national reference centre for H. influenzae during the year 2017 (n = 138) were characterized by whole genome sequencing (WGS), serotyping and antibiotic susceptibility testing. We also included 100 isolates that were received from non-invasive infections. FINDINGS: Most of the non-invasive isolates were non-typeable (99%) and this proportion was significantly less among invasive isolates 75%, p 

Original publication




Journal article


J Infect

Publication Date





7 - 14


Antibiotic resistance, Haemophilus influenzae, Infection, Typing, Whole genome sequencing, Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Typing Techniques, Cell Cycle Proteins, Cephalosporin Resistance, Child, Child, Preschool, Female, France, Genetic Variation, Genotype, Haemophilus Infections, Haemophilus influenzae, Humans, Infant, Infant, Newborn, Male, Middle Aged, Mutation, Missense, Serogroup, Young Adult