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The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

Original publication

DOI

10.1038/ncomms6890

Type

Journal article

Journal

Nat Commun

Publication Date

19/01/2015

Volume

6

Keywords

Genome-Wide Association Study, Software