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Although the increased risk of violent behavior in individuals with schizophrenia is now well-established, there is considerable uncertainty in pharmacological strategies to reduce this risk. In this review, we performed a systematic search of three electronic databases from January 2000 to March 2010 of treatment research on the management of violence in schizophrenia. We identified eight randomized controlled trials. The main findings included the association of nonadherence to antipsychotic medication to violent outcomes, a specific anti-aggressive effect of clozapine and short-term benefits of adjunctive β-blockers. There was little evidence on the efficacy of adjunctive mood stabilizers, depot medication or electroconvulsive therapy. Future research should use validated outcomes, longer follow-up periods and investigate patients with comorbid substance misuse.

Original publication




Journal article


Expert Rev Neurother

Publication Date





53 - 63


Adrenergic beta-Antagonists, Antipsychotic Agents, Clozapine, Comorbidity, Electroconvulsive Therapy, Female, Humans, Male, Medication Adherence, Randomized Controlled Trials as Topic, Schizophrenia, Substance-Related Disorders, Violence